Welcome to your Autonomic Drugs
1. A 3-year-old child is admitted after taking a drug from her parents' medicine cabinet. The signs suggest that the drug is an indirect-acting cholinomimetic with little or no CNS effect and a duration of action of about 2-4 h. Which of the following is the most likely cause of these effects?
2. Which of the following is a direct-acting cholinomimetic that is lipid-soluble and is used to facilitate smoking cessation?
3. Ms Brown has been treated for myasthenia gravis for several years. She reports to the emergency department complaining of recent onset of weakness of her hands, diplopia, and difficulty swallowing. She may be suffering from a change in response to her myasthenia therapy, that is, a cholinergic or a myasthenic crisis. Which of the following is the best drug for distinguishing between myasthenic crisis (insufficient therapy) and cholinergic crisis (excessive therapy)?
4. A crop duster pilot has been accidentally exposed to a high concentration of a highly toxic agricultural organophosphate insecticide. If untreated, the cause of death from such exposure would probably be
5. Mr Green has just been diagnosed with dysautonomia (chronic idiopathic autonomic insufficiency). You are considering different therapies for his disease. Pyridostigmine and neostigmine may cause which one of the following?
6. Parasympathetic nerve stimulation and a slow infusion of bethanechol will each:
7. Actions and clinical uses of muscarinic cholinoceptor agonists include which one of the following?
8. Which of the following effects is caused by the contraction of the ciliary muscle?
9. A 43-year-old man working in a vegetable field develops blurred vision, excessive tearing, difficulty breathing, and muscle weakness after exposure to a substance with a sulfur-like odor. What is the most likely cause of his symptoms?
10. Which of the following is the primary second-messenger process in the contraction of the ciliary muscle when focusing on near objects?
