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Dydrogesterone
Menstrual disorders (irregular, painful periods)
Premenstrual syndrome (PMS)
Endometriosis
Infertility due to luteal phase defect
Threatened or recurrent miscarriage
Hormone replacement therapy (HRT) support
Progestins (Synthetic Progesterone)
Duphaston contains dydrogesterone, a synthetic hormone that mimics natural progesterone. It helps regulate the menstrual cycle, supports the uterine lining for implantation and pregnancy, and counteracts the effects of unopposed estrogen in hormone replacement therapy.
Varies based on the condition being treated.
Menstrual irregularities: Usually 10 mg once or twice daily.
Support in pregnancy: As prescribed by your doctor.
HRT: Given alongside estrogen in a cyclic manner.
Note: Follow the exact dosage and duration prescribed by your healthcare provider.
Duphaston is generally well-tolerated. Possible side effects include:
Headache
Nausea
Breast tenderness
Bloating
Mood changes
Breakthrough bleeding
Allergic skin reactions (rare)
May interact with:
Rifampicin
Phenytoin
Carbamazepine
Barbiturates
Herbal products like St. John’s Wort
These may reduce Duphaston’s effectiveness by increasing its breakdown in the liver.
Known hypersensitivity to dydrogesterone
Undiagnosed vaginal bleeding
Liver dysfunction or liver disease
Known or suspected hormone-dependent tumors
Rule out hormone-sensitive cancers (e.g., breast or endometrial cancer) before use.
Regular monitoring advised if used for long-term hormone therapy.
Not for use as a contraceptive.
Should not be used alone in HRT; must be combined with estrogen.
Monitor liver function during prolonged use.
Breakthrough bleeding may occur; investigate if persistent.
Category B – Generally safe in pregnancy, especially in cases of threatened miscarriage or luteal phase support.
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
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